Get therapy, Drink Beer!
LOL
Get therapy, Drink Beer!
LOL
Cervantes (in Don Quixote) said, "Can we ever have too much of a good thing?"
I personally think this is wrong and it was actually a guy named Don Cerveza, and he said "Can we ever have too much beer? NO!"
Just a thought.
Spotted this in the wild today:
But 2013 is almost over so no idea why I haven't seen any yet!
In a pinch.
Wait are you telling me you still don't have Fat Tire there?????
LOL
None spotted yet but apparently it's on its way here.
Well, well, well... Look what I found today!
Readily available at a couple Kroger stores I ended up at.
Priced very well at $3 per bomber too, except the one on the left end. That one was $9 but it is a special release apparently.
Well, I'm giving the Fat Tire a try right now...
Poured an exceedingly clear amber color into an English Pint. Thick, cream colored head that is quite persistent. The nose on this isn't overly pronounced but I get malt and a little citrus. Taste is sour dough with a mild hoppiness. A fair bit of carbonation with a body on the thin side.
This isn't going to knock your socks off but it seems like a good, solid go-to beer that certainly won't break the bank.
Why drink the rice-water macrobrews when there are quality, inexpensive brews like this out there?
I don't get why anyone would drink commericalized rice crap... Bud Light? Coors? (I used to drink Coors, before I knew better). Budwiser?
Yuk.
Gross
Agreed. Fat Tire ain't my favorite. But is far better than BudMillerCrapJunk.
I will drink Fat Tire at places like Joe's Crab Shack - because frankly it's that or BudMillerCrapJunk... lol
But otherwise, I'll stick to an honest to goodness brew pub - that makes their own (but remember Fat Tire is local from new Belgium)... so it's better than the other stuff hands down.
Purchased a six of Tommyknocker Pick Axe IPA from Idaho Springs, CO this weekend. Had a nice hoppy note, bittersweet with touch of citrus but little finish. Wasn't disappointing, but I've had better.
If I had to choose... still the best I've had.
HAD to post this here... Ryan.... one for you!
(By the way, those are my personal favorites there in the picture, lol - Guinness and Jamisons)
Caffeine + alcohol keeps your chromosomes just right When cells divide, they must first replicate all of their genetic material. DNA replication is a very tightly controlled process; the double helix must be unwound, and the many enzymes involved must be coordinated to ensure that every nucleotide in each of our 46 chromosomes is copied exactly and only once. The system generally works pretty well, but the DNA replication machinery has a hard time with the ends of chromosomes, called telomeres.
The ends of your chromosomes are sensitive to a variety of environmental factors.
by Diana Gitig - Dec 17 2013, 11:05am MST
88
Now, researchers have found that caffeine makes it more difficult for cells to copy the ends of their chromosomes. But that may be OK, since they also found that booze has the opposite effect.
Telomeres protect the ends of chromosome. Embryonic cells have a special enzyme, telomerase, that lengthens telomeres; after the cells specialize, however, they stop expressing telomerase. From there on, telomeres get shorter with each cell division since they are so difficult to replicate. Once telomeres reach a critically short length, the cell stops dividing altogether. Shorter telomeres are thus a hallmark of aging. Tumor cells start re-expressing telomerase, and their lengthened telomeres are one factor that allows them to divide indefinitely.
Psychological stress and poor socioeconomic status have been linked to shortened telomeres. (Remember: longer telomeres = cancer, shorter telomeres = age.) However, it has not yet been determined if these stresses actually cause a change in telomere length, and if so, how that might occur; it's possible that they simply accelerate the normal trend of aging.
To explore the effects of stress on telomere length, a group at Tel Aviv University turned to yeast, a simpler organism that also maintains telomeres. To find any molecular mechanisms involved in changing telomere length, they grew yeast in the presence of thirteen different environmental stresses, measured the lengths of their telomeres, and then analyzed their gene expression profiles. They found that caffeine (and high temperatures) shorten telomeres, and alcohol (and acetic acid) lengthen them. Oxidative stress had no effect.
At least six percent of yeast genes—some 400 genes—are involved in regulating telomere length. To home in on which genes might be important in these stress responses, the researchers looked at mutants that showed atypical stress responses—yeast strains with telomeres that did not get shorter when they were exposed coffee (the yeast strains, not the researchers). The most prominent of these genes was Rif-1, a negative regulator of telomerase. They found that exposure to ethanol (and isopropanol, and methanol) reduced the recruitment of Rif1 to telomeres. About ten other genes were also identified as playing roles.
Some telomeres are too long, and some are too short. Perhaps striking the right balance of caffeine and alcohol is the key to keeping them just right—as if you needed an excuse to have another hot toddy.
PLoS Genetics, 2013. DOI: 10.1371/journal.pgen.1003721 (About DOIs).
I knew I was doing something right!
I think I need to keep my chromosomes just right.
I'm currently engaged in some chromosomal therapy () via a brew from local brewer, Quaff Brothers. This one was just released to bottle Friday and I made sure to grab some. It's called Grand Crow.
It is described as a "Belgian Quad aged in Ambler Whiskey Barrels with locally farmed blackberries" that comes in at 11.5%.
Poured a deep, hazy brown into a Trappist glass. Head is tan and fizzes away very quickly. Aroma is notably oak, caramel, and sweet blackberries. Taste is heavily bourbon, blackberries, and Belgian spice. The alcohol isn't very noticable. Moderate body with a dry finish.
Very tasty! With the fruit and bourbon, it is an interesting mix. I definitely like this one.
lol
"Our health and fitness pub offers deep chromosomal therapy... come in today for a glass or three!"
LOL
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